Recombinant Human CD157/BST1 Protein (Fc Tag)

• Background:

  CD38; also called ADP-ribosyl cyclase; is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family.It synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate; the former a second messenger for glucose-induced insulin secretion. And also moonlights as a receptor in cells of the immune system. CD38 is expressed in B and T lymphocytes; osteoclasts; and in cardiac; pancreatic; liver and kidney cells. Through its production of cyclic ADP-ribose; CD38 modulates calcium-mediated signal transduction in many types of cells; including neutrophils and pancreatic beta cells.

• Abbreviation:

  CD157; BST1

• Synonyms:

  ADP-ribosyl cyclase 2; BST-1; Bone marrow stromal antigen 1; Bone marrow stromal cell antigen 1; Cyclic ADP-ribose hydrolase 2

• UniProt:

  Q10588

• Accession Number:

  Q10588

• Expression System:

  HEK293 Cells

• Tag:

  C-Fc

• Sequence:

  Gly29-Lys292

• Field of Research:

  Signal Transduction; immunology

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  57.1 kDa

• Observed Molecular Weight:

  75 kDa

• Species:

  Human