Recombinant Human GITR/TNFRSF18 Protein (mFc Tag)

• Background:

  Tumor necrosis factor receptor superfamily member 18 (Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1; TRAF2; and TRAF3; but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

• Abbreviation:

  GITR; TNFRSF18

• Synonyms:

  AITR; CD357; GITR; Glucocorticoid-induced TNFR-related protein; TNFRSF18; Tumor necrosis factor receptor superfamily member 18

• UniProt:

  Q9Y5U5

• Accession Number:

  Q9Y5U5

• Expression System:

  HEK293 Cells

• Tag:

  C-mFc

• Sequence:

  Gln26-Glu161 (Thr45Ala)

• Field of Research:

  Signal Transduction; Cancer; immunology

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 90 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  41.1 kDa

• Observed Molecular Weight:

  40-55 kDa

• Species:

  Human