Recombinant Human STAT6 Protein (E.coli, His Tag)

Recombinant Human STAT6 Protein (E.coli, His Tag)

• Background: Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the STAT family of transcription factors. At least seven STATs exist: STAT1, 2, 3, 4, 5a, 5b, and 6. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. STAT6 plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. STAT6 has been shown to interact with EP300, CREB-binding protein, NFKB1, Nuclear receptor coactivator 1, IRF4 and SND1.
• Abbreviation: STAT6
• Synonyms: IL-4 Stat, IL-4-STAT, STAT6, STAT6B, STAT6C, Signal Transducer and Activator of Transcription 6
• CAS Number: 9000-83-3
• UniProt: P42226
• Accession Number: P42226
• Host: E. coli
• Origin Species: Human
• Tag: C-His
• Sequence: Ser627-Ser837
• Field of Research: Signal Transduction;Cancer;epigenetics and nuclear signal;
• Purity: > 85 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 30 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.