Recombinant Human β-Defensin 4A/DEFB4A Protein

Recombinant Human β-Defensin 4A/DEFB4A Protein

• Background: β-Defensin 4A is a membrane-active cationic peptide that functions in inflammation and innate immune responses. There are at least 30 β-Defensins, which are distinguished from α-Defensins by the connectivity pattern of their three intermolecular disulfide bonds. Members of the Defensin family are highly similar in protein sequence. This gene encodes Defensin, DEFB4;, which has broad-spectrum antimicrobial activity and may play an important role in innate epithelial defense. They are highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. β-Defensin 4A has low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. The 45 amino acid mature human BD3 shares 38% and 33% amino acid sequence identity with mouse and rat BD3, respectively.
• Abbreviation: β-Defensin 4A;DEFB4A
• Synonyms: BD-2, Beta 2, Beta-Defensin 2, Beta-Defensin 4A, DEFB102, DEFB2, DEFB4, DEFB4A, DEFB4B, Defensin, SAP1, Skin-Antimicrobial Peptide 1, hBD-2
• CAS Number: 9000-83-3
• UniProt: O15263
• Accession Number: O15263
• Host: E. coli
• Origin Species: Human
• Tag: None
• Sequence: Gly24-Pro64
• Field of Research: Microbiology
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 9 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.