Recombinant Human Pro-Neuregulin-1/NRG1-β1 Protein (aa 2-246)
CAT:
763-PKSH032939-01
Size:
50 µg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Human Pro-Neuregulin-1/NRG1-β1 Protein (aa 2-246)
- Background: Pro-neuregulin-1;Neuregulin-1 beta 1（NRG1） is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors; resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial; glial; neuronal; and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.
- Abbreviation: Pro-Neuregulin-1;NRG1-β1
- Synonyms: EGF, GGF, HGL, HRG1-beta 1, HRGA, NDF, NRG1, NRG1-beta 1, Neuregulin-1 beta 1, Pro-neuregulin-1, SMDF
- CAS Number: 9000-83-3
- UniProt: Q02297
- Accession Number: AAA58639.1
- Host: E. coli
- Origin Species: Human
- Tag: None
- Sequence: Ser2-Lys246
- Field of Research: Neuroscience
- Purity: > 85 % as determined by reducing SDS-PAGE.
- Bioactivity: Not validated for activity
- Reconstitution: Please refer to the printed manual for detailed information.
- Molecular Weight: 34 kDa
- Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
- Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.