Recombinant Human Neuregulin-1/NRG1-β1 Protein (EGF Domain, Fc Tag)

Recombinant Human Neuregulin-1/NRG1-β1 Protein (EGF Domain, Fc Tag)

• Background: Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development; neurotransmission; and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems; and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder; with etiology likely due to epistasis.
• Synonyms: EGF, GGF, HGL, HRG1-beta 1, HRGA, NDF, NRG1, NRG1-beta 1, Neuregulin-1 beta 1, Pro-neuregulin-1, SMDF
• CAS Number: 9000-83-3
• UniProt: Q02297
• Accession Number: Q02297-6
• Host: HEK293 Cells
• Origin Species: Human
• Tag: N-hFc
• Sequence: Thr 176-Lys 246
• Applications: ELISA
• Field of Research: Neuroscience
• Purity: > 86 % as determined by reducing SDS-PAGE.
• Bioactivity: 1. Immobilized Rhesus ErbB3 at 2 μg/mL (100 μl/well) can bind human NRG1 (isoform Beta1), The EC50 of human NRG1 (isoform Beta1) is 0.58 μg/mL. 2. Immobilized human ErbB3 at 2 μg/mL (100 μl/well) can bind human NRG1 (isoform Beta1), The EC50 of human NRG1 (isoform Beta1) is 0.43 μg/mL.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 38 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.