Recombinant Human Parathyroid Hormone/PTH Protein (1-84)

• Background:

  Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid. This hormone is secreted from cells of the parathyroid glands and finds its major target cells in bone and kidney. Another hormone; parathyroid hormone-related protein; binds to the same receptor as parathyroid hormone and has major effects on development. Like most other protein hormones; parathyroid hormone is synthesized as a preprohormone. After intracellular processing; the mature hormone is packaged within the Golgi into secretory vesicles; the secreted into blood by exocytosis. Parathyroid hormone is secreted as a linear protein of 84 amino acids.

• Abbreviation:

  PTH

• Synonyms:

  PTH; PTH1; Parathormone; Parathyrin; Parathyroid Hormone

• UniProt:

  P01270

• Accession Number:

  P01270

• Expression System:

  E.coli

• Tag:

  None

• Sequence:

  Ser32-Gln115

• Field of Research:

  Signal Transduction

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  9.4 kDa

• Observed Molecular Weight:

  14 kDa

• Species:

  Human