Recombinant Human Interleukin-17F/IL-17F Protein

Recombinant Human Interleukin-17F/IL-17F Protein

• Background: Interleukin-17F (IL-17F) exists in a disulfide-linked heterodimer that belongs to the IL-17 family. IL-17F is expressed in activated; but not resting; CD4+ T-cells and activated monocytes. IL-17F has been shown to stimulate the production of several other cytokines; including IL-6; IL-8; and granulocyte colony-stimulating factor. IL-17F can regulate cartilage matrix turnover and stimulates PBMC and T-cell proliferation. IL-17F is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2; TGFB1/TGFB; and monocyte chemoattractant protein-1. Defects in IL-17F are the cause of familial candidiasis type 6 (CANDF6).
• Abbreviation: Interleukin-17F;IL-17F
• Synonyms: Cytokine ML, Interleukin, CANDF, IL17F, CANDF6, IL-17F, ML-1, ML1, Cytokine ML-1, IL24, IL-24, Interleukin-17F, Interleukin-24
• CAS Number: 9000-83-3
• UniProt: Q96PD4
• Accession Number: AAH70124.1
• Host: HEK293 Cells
• Origin Species: Human
• Tag: None
• Sequence: Arg31-Gln163
• Field of Research: Cardiovascular;Cancer;immunology
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 18 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.