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Recombinant Human Interferon Lambda-2/IL-28A Protein (His Tag)

CAT: 0763-PKSH032602-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0763-PKSH032602-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IL-28A (Interferon-λ2, IFN-λ2), IL-28B/IFN-λ3, and IL-29/IFN-λ1 are type III interferons which are distantly related to IL-10 family and type I IFN family cytokines. Mature human IL-28A is an approximately 22-25 kDa protein that shares 66% amino acid (aa) sequence identity with mouse and rat IL-28A and shows cross-species activity. It shares 96% and 70% aa sequence identity with human IL-28B and IL-29, respectively. IL-28A promotes the Th1 polarization of dendritic cells in the airway and inhibits Th2 and Th17 mediated inflammation. IL-28A additionally exhibits anti-tumor activity, in part by enhancing IL-12 dependent anti-tumor CTL responses in vivo. In contrast, it is up-regulated in invasive bladder cancer where it promotes tumor cell migration.
Abbreviation
Interferon Lambda-2; IL-28A
Synonyms
IFN-lambda; Cytokine Zcyto; Interferon lambda; Ifnl; ZCYTO; IFN-λ; Cytokine Zcyto20; IFN-lambda-2; IFN-λ2; IL-28A; Interferon lambda-2; Interleukin-28A; IL28A; ZCYTO20; IFNL2; ZCYTO20
UniProt
Q8IZJ0
Accession Number
Q8IZJ0
Expression System
HEK293 Cells
Tag
C-His
Sequence
Val26-Val200
Field of Research
Microbiology; immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
20.6 kDa
Observed Molecular Weight
20 kDa
Species
Human

UniProtKB · Q8IZJ0

Interferon lambda-2

IFNL2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8IZJ0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IFNL2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IFN-lambda-2
EC number
—
Processing
Precursor
Secondary accessions
Q45KQ8, Q6VN55, Q8IWL7
Protein keywords

Biological process

Antiviral defense

Molecular function

Cytokine

PTM

Disulfide bond

Technical term

Proteomics identificationReference proteome

Cellular component

Secreted

Domain

Signal
Product Datasheet
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