Recombinant Human Interferon Lambda-2/IL-28A Protein (His Tag)
CAT:
763-PKSH032602-02
Size:
10 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Human Interferon Lambda-2/IL-28A Protein (His Tag)
- Background: IL-28A (Interferon-λ2,IFN-λ2), IL-28B/IFN-λ3, and IL-29/IFN-λ1 are type III interferons which are distantly related to IL-10 family and type I IFN family cytokines. Mature human IL-28A is an approximately 22-25 kDa protein that shares 66% amino acid (aa) sequence identity with mouse and rat IL-28A and shows cross-species activity. It shares 96% and 70% aa sequence identity with human IL-28B and IL-29, respectively. IL-28A promotes the Th1 polarization of dendritic cells in the airway and inhibits Th2 and Th17 mediated inflammation. IL-28A additionally exhibits anti-tumor activity, in part by enhancing IL-12 dependent anti-tumor CTL responses in vivo. In contrast, it is up-regulated in invasive bladder cancer where it promotes tumor cell migration.
- Abbreviation: Interferon Lambda-2;IL-28A
- Synonyms: IFN-lambda, Cytokine Zcyto, Interferon lambda, Ifnl, ZCYTO, IFN-λ, Cytokine Zcyto20, IFN-lambda-2, IFN-λ2, IL-28A, Interferon lambda-2, Interleukin-28A, IL28A, ZCYTO20, IFNL2, ZCYTO20
- CAS Number: 9000-83-3
- UniProt: Q8IZJ0
- Accession Number: Q8IZJ0
- Host: HEK293 Cells
- Origin Species: Human
- Tag: C-His
- Sequence: Val26-Val200
- Field of Research: Microbiology;immunology
- Purity: > 95 % as determined by reducing SDS-PAGE.
- Bioactivity: Not validated for activity
- Reconstitution: Please refer to the printed manual for detailed information.
- Molecular Weight: 20 kDa
- Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
- Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.