Recombinant Human BPGM Protein (His Tag)

CAT: 0763-PKSH032119-01Size: 10 µgDry Ice: NoHazardous: No

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CAT#:0763-PKSH032119-01Size:10 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Bisphosphoglycerate Mutase (BPGM) is a member of the Phosphoglycerate Mutase family and BPG-Dependent PGAM subfamily. BPGM is a multifunctional enzyme. BPGM catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. It also has phosphoglycerate phosphomutase activity. BPGM plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of 2,3-bisphosphoglycerate (2,3-BPG) . Deficiency of BPGM increases the affinity of cells for oxygen and result in hemolytic anemia.

Abbreviation

BPGM

Synonyms

2,3-Bisphosphoglycerate Mutase Erythrocyte;2,3-Bisphosphoglycerate Synthase;2,3-Diphosphoglycerate Mutase; BPG-Dependent PGAM; BPGM; Bisphosphoglycerate Mutase; DPGM

UniProt

P07738

Accession Number

P07738

Expression System

E.coli

Tag

C-His

Sequence

Ser2-Lys259

Field of Research

Signal Transduction; Cardiovascular; Cancer; metabolism

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

31.0 kDa

Observed Molecular Weight

30 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, pH 8.0.

Species

Human

UniProtKB · P07738

Bisphosphoglycerate mutase

PMGE_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P07738
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: BPGM
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: BPGM
EC number: 5.4.2.4
Processing: —
Secondary accessions: A4D1N9

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationGlycationGlycoproteinPhosphoprotein

Disease

Congenital erythrocytosisDisease variantHereditary hemolytic anemia

Biological process

Glycolysis

Molecular function

HydrolaseIsomerase

Product Datasheet

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