Recombinant Human BCL-W/BCL2L2 Protein (His Tag)

• Background:

  Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. Furthermore, BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

• Abbreviation:

  BCL-W; BCL2L2

• Synonyms:

  Apoptosis Regulator Bcl-W; BCL2L2; BCLW; Bcl-2-Like Protein 2; Bcl2-L-2; KIAA0271

• UniProt:

  Q92843

• Accession Number:

  AAI13523.1

• Expression System:

  E.coli

• Tag:

  C-His

• Sequence:

  Ala2-Thr172

• Field of Research:

  Cell biology; Cancer

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Not Applicable

• Shipping Conditions:

  This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

• Storage Conditions:

  Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

• Calculated Molecular Weight:

  19.9 kDa

• Observed Molecular Weight:

  18 kDa

• Formulation:

  Supplied as a 0.2 μm filtered solution of 25mM HEPES, 100mM KCl, 20% Glycerol, pH 7.5.

• Species:

  Human