Recombinant Human Apolipoprotein A-I/ApoAI Protein

Recombinant Human Apolipoprotein A-I/ApoAI Protein

• Background: Apolipoprotein A1 (APOA1) is a secreted protein which belongs to the Apolipoprotein A1/A4/E family. APOA1 is the major protein component of high density lipoprotein (HDL) in plasma. APOA1 plays a critical role in various biological processes; such as Cholesterol metabolism; Lipid metabolism and transport; Steroid metabolism. APOA1 promotes cholesterol efflux from tissues to the liver and thus helps to clear cholesterol from arteries. Defects in this gene resulted in HDL deficiencies; including Tangier disease (TGD); systemic non-neuropathic amyloidosis; premature coronary artery disease; hepatosplenomegaly and progressive muscle wasting and weakness. In addition; ApoA-I is implicated in the anti-endotoxin function of HDL via interaction with lipopolysaccharide or endotoxin.
• Abbreviation: Apolipoprotein A-I;ApoAI
• Synonyms: APOA1, Apo-AI, ApoA-I, Apolipoprotein A-I, Apolipoprotein A1
• CAS Number: 9000-83-3
• UniProt: P02647
• Accession Number: P02647
• Host: E. coli
• Origin Species: Human
• Tag: None
• Sequence: Arg19-Gln267
• Field of Research: Signal Transduction;Cardiovascular;Neuroscience;Cancer;metabolism;
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 25-31 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.