Recombinant Human TGFB1/TGF-beta 1 Protein
CAT:
763-PKSH032007-01
Size:
50 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Human TGFB1/TGF-beta 1 Protein
- Background: Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone; articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions; including the control of cell growth; cell proliferation; cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
- Abbreviation: TGFB1;TGF-beta 1
- Synonyms: CED, DPD1, LAP, Latency-Associated Peptide, TGF-Beta-1, TGF-beta 1, TGFB, TGFB1, Transforming Growth Factor Beta-1
- CAS Number: 9000-83-3
- UniProt: P01137
- Accession Number: P01137
- Host: CHO Stable Cells
- Origin Species: Human
- Tag: None
- Sequence: Ala279-Ser390
- Applications: Cell culture
- Field of Research: Signal Transduction;Cell biology;Cardiovascular;Cancer;metabolism;Stem cells
- Purity: > 95 % as determined by reducing SDS-PAGE.
- Bioactivity: Measured by its ability to inhibit the IL-4-dependent proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is 4-40 pg/ml
- Reconstitution: Please refer to the printed manual for detailed information.
- Molecular Weight: 13 kDa
- Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
- Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.