Recombinant Human PGD2 Synthase/PTGDS Protein (His Tag)

Recombinant Human PGD2 Synthase/PTGDS Protein (His Tag)

• Background: PTGDS; also known as L-PGDS; belongs to the calycin superfamily;lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic molecules such as steroids; bilins; retinoids; and lipids. PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of PGH2 to PGD2. It is involved in smooth muscle contraction/relaxation and a variety of central nervous system functions. PTGDS may have an anti-apoptotic role in oligodendrocytes. It binds small non-substrate lipophilic molecules; including biliverdin; bilirubin; retinal; retinoic acid and thyroid hormone; and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
• Synonyms: Beta-Trace Protein, Cerebrin-28, Glutathione-Independent PGD Synthase, Lipocalin-Type Prostaglandin-D Synthase, PDS, PGD2 Synthase, PGDS, PGDS2, PTGDS, Prostaglandin D Synthase, Prostaglandin-D2 Synthase, Prostaglandin-H2 D-Isomerase
• CAS Number: 9000-83-3
• UniProt: P41222
• Accession Number: P41222
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-His
• Sequence: Met 1-Gln190
• Field of Research: Signal Transduction;
• Purity: > 80 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 28 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.