Recombinant Human PGD2 Synthase/PTGDS Protein (His Tag)

Recombinant Human PGD2 Synthase/PTGDS Protein (His Tag)

• Background: Prostaglandin-H2 D-Isomerase (PTGDS) belongs to the Lipocalin family of calycin superfamily. PTGDS is preferentially expressed in the brain. PTGDS catalyzes the conversion of PGH2 to PGD2; a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. PTGDS is involved in a variety of CNS functions; such as sedation; REM sleep and PGE2-induced allodynia; and may have an anti-apoptotic role in oligodendrocytes. PTGDS binds small non-substrate lipophilic molecules and may act as a scavenger for harmful hydrophopic molecules and a secretory retinoid and thyroid hormone transporter. It possibly participates in development and maintenance of the blood-brain; blood-retina; blood-aqueous humor; blood-testis barrier; the central nervous system and male reproductive system.
• Abbreviation: PGD2 Synthase;PTGDS
• Synonyms: Beta-Trace Protein, Cerebrin-28, Glutathione-Independent PGD Synthase, Lipocalin-Type Prostaglandin-D Synthase, PDS, PGD2 Synthase, PGDS, PGDS2, PTGDS, Prostaglandin D Synthase, Prostaglandin-D2 Synthase, Prostaglandin-H2 D-Isomerase
• CAS Number: 9000-83-3
• UniProt: P41222
• Accession Number: P41222
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-His
• Sequence: Ala23-Gln190
• Field of Research: Signal Transduction;
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Not Applicable
• Molecular Weight: 20-27 kDa
• Shipping Conditions: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
• Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.