Recombinant Human SRC Kinase/c-SRC Protein (His & GST Tag)

Recombinant Human SRC Kinase/c-SRC Protein (His & GST Tag)

• Background: Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C-SRC and V-SRC. C-SRC is only activated under certain circumstances where it is required such as growth factor signaling, while V-SRC is a constitutively active as opposed to normal SRC (C-SRC). Thus, V-SRC is an instructive example of an oncogene protein kinase whereas C-SRC is a proto-oncogene protein kinase. Inhibition of SRC with NR2A tyrosine phosphorylation mediated by PSD-95 may contribute to the lithium-induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity.
• Synonyms: ASV, SRC1, c-SRC, p60-Src
• CAS Number: 9000-83-3
• UniProt: P12931
• Accession Number: P12931-1
• Host: Baculovirus
• Origin Species: Human
• Tag: N-His-GST
• Sequence: Met 1-Leu 536
• Applications: Enzyme
• Field of Research: Signal Transduction,Epigenetics and Nuclear Signaling,Cancer
• Purity: > 90 % as determined by reducing SDS-PAGE.
• Bioactivity: The specific activity was determined to be > 80 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.
• Reconstitution: Not Applicable
• Molecular Weight: 81 kDa
• Shipping Conditions: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
• Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.