Recombinant Human SRC/Proto-oncogene c-Src Protein (His Tag)

Recombinant Human SRC/Proto-oncogene c-Src Protein (His Tag)

• Background: Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C-SRC and V-SRC. C-SRC is only activated under certain circumstances where it is required such as growth factor signaling, while V-SRC is constitutively active as opposed to normal SRC (C-SRC). Thus, V-SRC is an instructive example of an oncogene protein kinase whereas C-SRC is a proto-oncogene protein kinase. Inhibition of SRC with NR2A tyrosine phosphorylation mediated by PSD-95 may contribute to the lithium-induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity.
• Abbreviation: SRC;Proto-oncogene c-Src
• Synonyms: Proto-oncogene c-Src, Proto-oncogene tyrosine-protein kinase Src, SRC1, p60-Src, pp60c-src
• CAS Number: 9000-83-3
• UniProt: P12931
• Accession Number: P12931-1
• Host: E. coli
• Origin Species: Human
• Tag: N-His
• Sequence: Gly2-Gly287
• Field of Research: Signal Transduction,Epigenetics and Nuclear Signaling,Cancer
• Purity: > 90% as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
• Molecular Weight: 32.4 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.