Recombinant Human CD20/MS4A1 Protein (TrxA Tag)

• Background:

  CD20 (membrane-spanning 4-domains; subfamily A; member 1) ; also known as MS4A1; is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed on all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells; but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) . CVID5 is a primary immunodeficiency characterized by antibody deficiency; hypogammaglobulinemia; recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range; but can be low.

• Synonyms:

  B1; Bp35; CD20; CVID5; LEU-16; MS4A1; MS4A2; S7

• UniProt:

  P11836

• Accession Number:

  NP_068769.2

• Expression System:

  E.coli

• Tag:

  N-Trx

• Sequence:

  Ile 141-Ser 188

• Field of Research:

  Cancer; immunology; Stem cells

• Endotoxin:

  Please contact us for more information.

• Purity:

  > 80 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  23.9 kDa

• Species:

  Human