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CAT: 0804-HY-101507-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-101507-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (-) -englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8[1].

CAS Number

1628287-16-0

Product Name Alternative

Pico145; HC-608

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Pico145.html

Purity

99.47

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1C2=C(N=C(OC3=CC=CC(OC(F)(F)F)=C3)N2CC4=CC=C(Cl)C=C4)N(C)C(N1CCCO)=O

Molecular Formula

C23H20ClF3N4O5

Molecular Weight

524.88

Precautions

H302, H315, H319

References & Citations

[1]Rubaiy HN, et al. Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels. J Biol Chem. 2017 May 19;292 (20) :8158-8173.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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