IL18 Polyclonal Antibody

• Background :

  Interleukin-18 (L-18) is a cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12 it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS) . After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production in B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.

• Abbreviation :

  IL18

• UniProt :

  P70380

• Host :

  Rabbit

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Recombinant fusion protein of mouse IL18

• Target :

  Ig; Il-; Igif; Il-18

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB; IHC

• Purification :

  Affinity purification

• Concentration :

  1mg/mL

• Dilution :

  WB 1:500-1:2000; IHC 1:50-1:200

• Buffer :

  PBS with 0.05% proclin300,50% glycerol, pH7.3.

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  22kDa

• Observed Molecular Weight :

  22kDa/18kDa

• Isotype :

  IgG