IL10 Polyclonal Antibody

• Background:

  Interleukin (IL) -10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

• Abbreviation:

  IL10

• UniProt:

  P18893 , P29456

• Host:

  Rabbit

• Reactivity:

  Mouse; Rat

• Immunogen:

  KLH conjugated Synthetic peptide corresponding to IL-10

• Target:

  CSIF; Cytokine synthesis inhibitory factor; GVHDS; IL 10; IL-10; IL10; IL10; IL10A; Interleukin 10; Interleukin-10; MGC126450; MGC126451; T-cell growth inhibitory factor; TGIF

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  IHC; IF

• Field of Research:

  Cancer; Immunology

• Purification:

  Affinity purification

• Concentration:

  150 μg/mL

• Dilution:

  IHC 1:200-1:1000; IF 1:200-1:1000

• Buffer:

  PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Citation 01:

  https://www.hindawi.com/journals/omcl/2022/8244497/

• Isotype:

  IgG