SLC7A11/xCT Polyclonal Antibody

CAT: 0763-E-AB-93104-01Size: 60 µLDry Ice: NoHazardous: No

1 / 1

CAT#:0763-E-AB-93104-01Size:60 µL

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Background

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc (-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

Abbreviation

SLC7A11/xCT

UniProt

Q9UPY5

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

A synthetic peptide of human SLC7A11/xCT

Target

SLC7A11; CCBR1; xCT

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

Field of Research

Cancer; Cell Biology; Metabolism; Signal Transduction

Purification

Affinity purification

Concentration

1mg/mL

Dilution

WB 1:500-1:2000

Buffer

PBS with 0.05% proclin300,50% glycerol, pH7.3.

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

55kDa

Observed Molecular Weight

55KDa

Isotype

IgG

UniProtKB · Q9UPY5

Cystine/glutamate transporter

XCT_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9UPY5
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: SLC7A11
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A8K2U4

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Amino-acid transportTransport

Cellular component

Cell membraneCell projectionLysosomeMembrane

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Domain

TransmembraneTransmembrane helix

Product Datasheet

Related Products

Catalog	Name
E-AB-17625-01	SLC7A11 Polyclonal Antibody
AN301376L	Recombinant xCT Monoclonal Antibody
E-AB-90592-01	SLC5A11 Polyclonal Antibody
E-AB-17981-01	SLC6A11 Polyclonal Antibody
E-AB-12479-01	SLC2A11 Polyclonal Antibody
E-AB-90294-01	SLC6A11 Polyclonal Antibody
E-AB-90682-01	SLC4A10 Polyclonal Antibody
E-AB-90166-01	SLC6A15 Polyclonal Antibody
E-AB-10597-01	SLC25A11 Polyclonal Antibody
E-AB-90215-01	SLC6A14 Polyclonal Antibody

Alternative Products

Catalog	Name
MBS2575795-01	SLC7A11/xCT Polyclonal Antibody
TA333870	xCT (SLC7A11) Rabbit Polyclonal Antibody
GTR18608565	XCT/SLC7A11 Rabbit Polyclonal Antibody
AF7992	SLC7A11/xCT Rabbit Polyclonal Antibody
TA303158	xCT (SLC7A11) Goat Polyclonal Antibody
APR10142G	Polyclonal SLC7A11 / XCT Antibody (Internal)
GTR18614133	XCT/SLC7A11 Rabbit Polyclonal Antibody (APC)
GTR18614132	XCT/SLC7A11 Rabbit Polyclonal Antibody (PE)
GTR18757306	XCT/SLC7A11 Rabbit Polyclonal Antibody (Fluoro488)
APR10143G	Polyclonal SLC7A11 / XCT Antibody (N-Terminus)