Recombinant CDC42 Monoclonal Antibody

• Background:

  The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.

• Abbreviation:

  CDC42

• UniProt:

  P60953

• Host:

  Rabbit

• Reactivity:

  Human; Rat

• Immunogen:

  Recombinant protein of human CDC42

• Target:

  CDC42; CDC42Hs; G25K; TKS

• Clonality:

  Monoclonal

• Clone:

  R01-1C7

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Signal Transduction

• Purification:

  Affinity Purified

• Concentration:

  300 μg/mL

• Dilution:

  WB 1:1000-1:2000

• Buffer:

  50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  21kDa

• Observed Molecular Weight:

  21kDa

• Isotype:

  IgG