Recombinant Collagen I alpha 1 Monoclonal Antibody

• Background:

  COL1A1 (Collagen Type I Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL1A1 include Caffey Disease and Osteogenesis Imperfecta, Type I. Among its related pathways are Collagen chain trimerization and Transcription_Role of VDR in regulation of genes involved in osteoporosis. GO annotations related to this gene include identical protein binding and platelet-derived growth factor binding. An important paralog of this gene is COL2A1.This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

• Abbreviation:

  Collagen I alpha 1

• UniProt:

  P02452

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant protein of human Collagen I

• Target:

  COL1A1; Alpha 1 type I collagen; Alpha-1 type I collagen; CO1A1; COL1A1; Collagen alpha-1 (I) chain; Collagen type I alpha 1; Procollagen type I C terminal propeptide

• Clonality:

  Monoclonal

• Clone:

  R02-5E5

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Signal Transduction

• Purification:

  Affinity Purified

• Concentration:

  300 μg/mL

• Dilution:

  WB 1:500-1:1000

• Buffer:

  50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  139kDa

• Observed Molecular Weight:

  139kDa

• Citation 01:

  https://onlinelibrary.wiley.com/doi/abs/10.1111/tmi.13359

• Isotype:

  IgG