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MTOR Polyclonal Antibody

CAT: 0763-E-AB-70304-01Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-70304-01Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MTOR, also named as FRAP1, FRAP, FRAP2 and RAPT1, belongs to the PI3/PI4-kinase family. MTOR is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. MTOR is Kinase subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. The antibody is specific to MTOR.
Abbreviation
MTOR
UniProt
P42345, Q9JLN9, P42346
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein corresponding to Mouse mTOR
Target
DJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1) ; FK506 binding protein 12 rapamycin associated protein 1; FK506 binding protein 12 rapamycin associated protein 2; FK506 binding protein 12 rapamycin complex associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP rapamycin associated protein; FKBP12 rapamycin complex associated protein; FKBP12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; FLJ44809; FRAP; FRAP1; FRAP2; Mammalian target of rapamycin; Mechanistic target of rapamycin; mTOR; MTOR; OTTHUMP00000001983; RAFT1; Rapamycin and FKBP12 target 1; Rapamycin associated protein FRAP2; Rapamycin target protein 1; Rapamycin target protein; RAPT1; Serine/threonine-protein kinase mTOR
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Cell Biology; Cardiovascular; Epigenetics and Nuclear Signaling; Metabolism
Purification
Affinity purification
Concentration
0.8 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
289kDa
Observed Molecular Weight
289kDa
Citation 01
https://www.mdpi.com/2072-6694/12/1/87
Citation 02
https://www.frontiersin.org/articles/10.3389/fonc.2019.01469/full
Citation 03
https://www.mdpi.com/1420-3049/23/8/2047
Isotype
IgG
Product Datasheet
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