BECN1 Polyclonal Antibody

• Background :

  Beclin-1 (BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.

• Abbreviation :

  BECN1

• UniProt :

  Q14457, O88597, Q91XJ1

• Host :

  Rabbit

• Reactivity :

  Human; Mouse

• Immunogen :

  KLH conjugated Synthetic peptide corresponding to Mouse Beclin1

• Target :

  APG6; ATG 6; ATG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; Beclin 1 (coiled coil moesin like BCL2 interacting protein) ; Beclin 1 autophagy related; Beclin-1; Beclin1; BECN 1; Becn1; BECN1; Coiled coil myosin like BCL2 interacting protein; Coiled-coil myosin-like BCL2-interacting protein; GT197; Protein GT197; VPS 30; VPS30

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  IHC; IF

• Field of Research :

  Cancer; Epigenetics and Nuclear Signaling; Metabolism; Microbiology; Signal Transduction

• Purification :

  Affinity purification

• Concentration :

  2.6 mg/mL

• Dilution :

  IHC 1:300-1:1000; IF 1:100-1:500

• Buffer :

  PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Isotype :

  IgG