BECN1 Polyclonal Antibody

CAT: 0763-E-AB-70093-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0763-E-AB-70093-01Size:60 μL
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Background
Beclin-1 (BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.
Abbreviation
BECN1
UniProt
Q14457, O88597, Q91XJ1
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse Beclin1
Target
APG6; ATG 6; ATG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; Beclin 1 (coiled coil moesin like BCL2 interacting protein) ; Beclin 1 autophagy related; Beclin-1; Beclin1; BECN 1; Becn1; BECN1; Coiled coil myosin like BCL2 interacting protein; Coiled-coil myosin-like BCL2-interacting protein; GT197; Protein GT197; VPS 30; VPS30
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC; IF
Field of Research
Cancer; Epigenetics and Nuclear Signaling; Metabolism; Microbiology; Signal Transduction
Purification
Affinity purification
Concentration
2.6 mg/mL
Dilution
IHC 1:300-1:1000; IF 1:100-1:500
Buffer
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

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