OCT4 Polyclonal Antibody

• Background:

  This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.

• Abbreviation:

  OCT4

• UniProt:

  Q01860

• Host:

  Rabbit

• Reactivity:

  Human; Mouse

• Immunogen:

  A synthetic peptide of human OCT4

• Target:

  POU5F1; OCT3; OCT4; OTF-3; OTF3; OTF4; Oct-3; Oct-4

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC

• Field of Research:

  Cancer; Epigenetics and Nuclear Signaling; Developmental Biology; Stem Cells

• Purification:

  Affinity purification

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000; IHC 1:50-1:200

• Buffer:

  PBS with 0.05% proclin300,50% glycerol, pH7.3.

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  30kDa/38kDa

• Observed Molecular Weight:

  45KDa

• Isotype:

  IgG