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Histone H2AX Polyclonal Antibody

CAT: 0763-E-AB-67407-01Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-67407-01Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.
Abbreviation
Histone H2AX
UniProt
P16104
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
A synthetic peptide of human Histone H2AX.
Target
H2A.X; H2A/X; H2AX; Histone H2AX; H2AFX; histone H2AX; gamma H2A.X; γH2AX
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IF
Field of Research
Cancer; Epigenetics and Nuclear Signaling
Purification
Affinity purification
Concentration
1mg/mL
Dilution
IF 1:50-1:100
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · P16104

Histone H2AX

H2AX_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16104
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
H2AX
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
H2a/x
EC number
—
Processing
—
Secondary accessions
Q4ZGJ7, Q6IAS5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Biological process

Cell cycleDNA damageDNA recombinationDNA repairHost-virus interactionMeiosis

Cellular component

ChromosomeNucleosome coreNucleus

Molecular function

DNA-binding

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