PFKFB3 Polyclonal Antibody

• Background:

  The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• Abbreviation:

  PFKFB3

• UniProt:

  Q16875

• Host:

  Rabbit

• Reactivity:

  Human; Rat

• Immunogen:

  Synthetic peptide of human PFKFB3

• Target:

  Renal Carcinoma Antigen NY-REN-56; PFK/FBPase 3; IPFK2; PFK2

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Cardiovascular; Signal Transduction; Neuroscience; Cancer; Metabolism

• Purification:

  Antigen affinity purification

• Concentration:

  0.5 mg/mL

• Dilution:

  WB 1:500-1:2000

• Buffer:

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  60 kDa

• Observed Molecular Weight:

  Refer to figures

• Isotype:

  IgG