BECN1 Polyclonal Antibody

• Background :

  Beclin-1 (BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.

• Abbreviation :

  BECN1

• UniProt :

  Q14457

• Host :

  Rabbit

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthetic peptide of human BECN1

• Target :

  APG6; ATG 6; ATG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; Beclin 1 (coiled coil moesin like BCL2 interacting protein) ; Beclin 1 autophagy related; Beclin-1; Beclin1; BECN 1; Becn1; BECN1; Coiled coil myosin like BCL2 interacting protein; Coiled-coil myosin-like BCL2-interacting protein; GT197; Protein GT197; VPS 30; VPS30

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB; IHC

• Field of Research :

  Cancer; Epigenetics and Nuclear Signaling; Metabolism; Microbiology; Signal Transduction

• Purification :

  Antigen affinity purification

• Concentration :

  0.84 mg/mL

• Dilution :

  WB 1:500-1:2000; IHC 1:50-1:100

• Buffer :

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  52 kDa

• Observed Molecular Weight :

  Refer to figures

• Citation 01 :

  https://www.sciencedirect.com/science/article/pii/S0020138322006258

• Citation 02 :

  https://www.tandfonline.com/doi/abs/10.1080/01616412.2022.2159109

• Isotype :

  IgG