EIF3C Polyclonal Antibody

CAT: 0763-E-AB-52777-02Size: 60 µLDry Ice: NoHazardous: No

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CAT#:0763-E-AB-52777-02Size:60 µL

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Background

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815) . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC) . The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632) . The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773) .

Abbreviation

EIF3C

UniProt

Q99613

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Fusion protein of human EIF3C

Target

Cell migration inducing protein 17; eIF 3c; eIF3 p110; eIF3-p110; eIF3c; EIF3C; EIF3CL; EIF3S8; EIF3S8 protein; Eukaryotic translation initiation factor 3 subunit 8 (110kD) ; Eukaryotic translation initiation factor 3 subunit 8 110kDa; Eukaryotic translation initiation factor 3 subunit 8; Eukaryotic translation initiation factor 3 subunit C

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Epigenetics and Nuclear Signaling

Purification

Antigen affinity purification

Concentration

0.6 mg/mL

Dilution

IHC 1:40-1:200

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG

UniProtKB · Q99613

Eukaryotic translation initiation factor 3 subunit C

EIF3C_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q99613
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: EIF3C
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: eIF3c
EC number: —
Processing: —
Secondary accessions: A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q9BW98

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Cellular component

Cytoplasm

Molecular function

Initiation factor

Biological process

Protein biosynthesis

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RD252777A-01	EIF3C Polyclonal Antibody
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