EIF3C Polyclonal Antibody

CAT: 0866-RD252777A-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:0866-RD252777A-01Size:20 µL
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815) . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC) . The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632) . The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773) .
Description
This is a EIF3C Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
Cell migration inducing protein 17, eIF 3c, eIF3 p110, eIF3-p110, eIF3c, EIF3C, EIF3CL, EIF3S8, EIF3S8 protein, Eukaryotic translation initiation factor 3 subunit 8 (110kD), Eukaryotic translation initiation factor 3 subunit 8 110kDa, Eukaryotic translation initiati
Swiss Prot
Q99613
Accession Number
BC001571
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein of human EIF3C
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
0.6 mg/mL
Dilution
IHC 1:40-1:200, ELISA 1:5000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

Popular Products