EIF3C Polyclonal Antibody

• Background :

  Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815) . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC) . The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632) . The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773) .

• Description :

  This is a EIF3C Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  Cell migration inducing protein 17, eIF 3c, eIF3 p110, eIF3-p110, eIF3c, EIF3C, EIF3CL, EIF3S8, EIF3S8 protein, Eukaryotic translation initiation factor 3 subunit 8 (110kD), Eukaryotic translation initiation factor 3 subunit 8 110kDa, Eukaryotic translation initiati

• Swiss Prot :

  Q99613

• Accession Number :

  BC001571

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Fusion protein of human EIF3C

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  IHC, ELISA

• Purification Method :

  Antigen affinity purification

• Assay Type :

  Antibody

• Concentration :

  0.6 mg/mL

• Dilution :

  IHC 1:40-1:200, ELISA 1:5000-1:10000

• Buffer :

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Storage Conditions :

  Store at -20°C. Avoid freeze / thaw cycles.

• Host or Source :

  Rabbit

• Isotype :

  IgG