TP53 Polyclonal Antibody

CAT: 0763-E-AB-52130-02Size: 60 µLDry Ice: NoHazardous: No

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CAT#:0763-E-AB-52130-02Size:60 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

TP53, also named as P53 and NY-CO-13, belongs to the p53 family. It has 9 isoforms. In SDS-Page, the MW is about 53kd. TP53 acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. It is involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. The antibody reacts specifically with 53 kDa protein.

Abbreviation

TP53

UniProt

P04637

Host

Rabbit

Reactivity

Human

Immunogen

Fusion protein of human TP53

Target

Antigen NY-CO-13; BCC7; Cellular tumor antigen p53; FLJ92943; LFS1; Mutant tumor protein 53; p53; p53 tumor suppressor; P53; Phosphoprotein p53; Tp53; Transformation related protein 53; TRP53; Tumor protein 53; Tumor protein p53; Tumor suppressor p53

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

Field of Research

Cancer; Cell Biology; Epigenetics and Nuclear Signaling

Purification

Antigen affinity purification

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

44 kDa

Observed Molecular Weight

Refer to figures

Isotype

IgG

UniProtKB · P04637

Cellular tumor antigen p53

P53_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P04637
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: TP53
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q2XN98, Q3LRW1, Q3LRW2, Q3LRW3, Q3LRW4, Q3LRW5, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationGlycoproteinIsopeptide bondMethylationPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-bindingRepressor

Coding sequence diversity

Alternative promoter usageAlternative splicing

Biological process

ApoptosisBiological rhythmsCell cycleHost-virus interactionNecrosisTranscriptionTranscription regulation

Cellular component

CytoplasmCytoskeletonEndoplasmic reticulumMitochondrionNucleus

Disease

Disease variantLi-Fraumeni syndromeTumor suppressor

Ligand

Metal-bindingZinc

Related Products

Catalog	Name
E-CL-R0677-01	Rat TP53 (Tumor Protein 53) CLIA Kit
E-EL-M1215	ELISA kit for Mouse TP53 (Tumor Protein p53)
PDEB100008-01	Recombinant Bovine P53/TP53 protein (His tag)
PDEB100002-01	Recombinant Bovine P53/TP53 protein (His tag)
E-CL-H0621-01	Human TP53 (Tumor Protein p53) CLIA Kit
E-EL-H0910-01	Human TP53 (Tumor Protein p53) ELISA Kit
E-CL-M0673-01	Mouse TP53 (Tumor Protein 53) CLIA Kit
E-EL-R1042	ELISA kit for Rat TP53 (Tumor Protein p53)
E-AB-65139-01	Polyclonal AntibodyPC1 Polyclonal Antibody
AN100004P	PAK1 Antibody Polyclonal Antibody

Alternative Products

Catalog	Name
MBS8571622-01	TP53 Polyclonal Antibody