GTPase Kras Polyclonal Antibody

CAT: 0763-E-AB-40639-01Size: 25 µLDry Ice: NoHazardous: No

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CAT#:0763-E-AB-40639-01Size:25 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

KRAS, also called p21, is a member of the Ras superfamily of proteins. It is located on human chromosome 12, and contains four coding exons and a 5' non-coding exon (PMID: 12778136) . KRAS is a membrane-anchored guanosine triphosphate/guanosine diphosphate (GTP/GDP) -binding protein and is widely expressed in most human cells. Like other members of the Ras family, the KRAS protein is a GTPase, and it is involved in intracellular signal transduction and mainly responsible for EGFR-signaling activation (PMID: 19117687) . KRAS mutations have been found in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma.

Abbreviation

KRAS

UniProt

P01116

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Human KRAS protein expressed by E.coli.

Target

KRAS; KRAS2; RASK2; GTPase Kras; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras; GTPase Kras

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

Field of Research

Cancer; Epigenetics and Nuclear Signaling; Signal Transduction

Purification

Antigen Affinity Purification

Concentration

1 mg/mL

Dilution

WB 1:1000-1:2000

Buffer

PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

21 kDa

Observed Molecular Weight

21 kDa

Isotype

IgG

UniProtKB · P01116

GTPase KRas

RASK_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P01116
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: KRAS
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 3.6.5.2
Processing: Precursor
Secondary accessions: A8K8Z5, B0LPF9, P01118, Q96D10

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationGlycoproteinIsopeptide bondLipoproteinMethylationPalmitatePrenylationUbl conjugation

Coding sequence diversity

Alternative splicing

Disease

CardiomyopathyDeafnessDisease variantEctodermal dysplasiaIntellectual disabilityProto-oncogene

Cellular component

Cell membraneCytoplasmMembrane

Ligand

GTP-bindingNucleotide-binding

Molecular function

Hydrolase

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Alternative Products

Catalog	Name
abx137610-01	GTPase KRas (KRAS) Antibody
RD86687A-01	GTPase Kras Polyclonal Antibody
abx317303-01	GTPase KRas (KRAS) Antibody (HRP)
abx449526	GTPase KRas (KRAS) Antibody (ATTO488)
abx449534	GTPase KRas (KRAS) Antibody (APC)
abx105485-01	GTPase KRas (KRAS) Antibody (Biotin)
abx106903-01	GTPase KRas (KRAS) Antibody (FITC)
abx370898-01	GTPase KRas (KRAS) Antibody Pair
abx449540	GTPase KRas (KRAS) Antibody (PE)
abx449528	GTPase KRas (KRAS) Antibody (ATTO594)