Lamin B1 Polyclonal Antibody

CAT: 0763-E-AB-40257-01Size: 25 µLDry Ice: NoHazardous: No

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CAT#:0763-E-AB-40257-01Size:25 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD) .

Abbreviation

Lamin B1

UniProt

P70615

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Rat Lamin-B1 protein expressed by E.coli

Target

ADLD; lamin B1; Lamin-B1; LMN; LMN2; LMNB; Lmnb1; LMNB1; MGC111419; OTTHUMP00000159218

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC; IF

Field of Research

Cancer; Cell Biology; Signal Transduction; Tags and Cell Markers

Purification

Antigen Affinity Purification

Concentration

1 mg/mL

Dilution

WB 1:250-1:500; IHC 1:200-1:600

Buffer

PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

67 kDa

Observed Molecular Weight

72 kDa

Citation 01

https://link.springer.com/article/10.1007/s12035-022-02923-2

Isotype

IgG

UniProtKB · P70615

Lamin-B1

LMNB1_RAT · Rattus norvegicus

View on UniProt ↗

Primary accession: P70615
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: Lmnb1
Protein existence: 1: Evidence at protein level
Organism: Rattus norvegicus (Rat)
Taxonomy ID: 10116
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: —

Protein keywords

PTM

AcetylationDisulfide bondGlycoproteinIsopeptide bondLipoproteinMethylationPhosphoproteinPrenylationUbl conjugation

Domain

Coiled coil

Technical term

Direct protein sequencingReference proteome

Cellular component

Intermediate filamentNucleus

Product Datasheet

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Alternative Products

Catalog	Name
APR00056G	Polyclonal Lamin A Antibody
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