SIRT1 Polyclonal Antibody

CAT: 0763-E-AB-32901-01Size: 20 µLDry Ice: NoHazardous: No

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CAT#:0763-E-AB-32901-01Size:20 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins witHuman, Mouseono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Abbreviation

SIRT1

UniProt

Q96EB6

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human SIRT1 around the non-phosphorylation site of Ser47.

Target

75SirT1; hSIR2; hSIRT1; HST2; S. cerevisiae; homolog of; NAD dependent deacetylase sirtuin 1; NAD dependent protein deacetylase sirtuin 1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; SIR1; SIR2; SIR2 like 1; SIR2 like protein 1; SIR2; S.cerevisiae; homolog-like 1; SIR2-like protein 1; SIR2ALPHA; SIR2L1; Sirt1; SirtT1 75 kDa fragment; Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) ; Sirtuin 1; Sirtuin type 1

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC-p; IF

Field of Research

Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Metabolism; Microbiology; Tags and Cell Markers

Purification

Affinity purification

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:50-1:200

Buffer

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

82kDa

Observed Molecular Weight

81kDa-120kDa

Citation 01

https://link.springer.com/article/10.1007/s12079-022-00703-0

Isotype

IgG

UniProtKB · Q96EB6

NAD-dependent protein deacetylase sirtuin-1

SIR1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q96EB6
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: SIRT1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: hSIRT1
EC number: 2.3.1.286
Processing: —
Secondary accessions: Q2XNF6, Q5JVQ0, Q9GZR9, Q9Y6F0

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationMethylationPhosphoproteinS-nitrosylationUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisBiological rhythmsDifferentiationHost-virus interactionMyogenesisTranscriptionTranscription regulation

Cellular component

CytoplasmMitochondrionNucleus

Molecular function

Developmental proteinTransferase

Ligand

Metal-bindingNADZinc

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