PERK Polyclonal Antibody

• Background:

  Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR) -induced G1 growth arrest due to the loss of cyclin D1.

• Abbreviation:

  PERK

• UniProt:

  Q9NZJ5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Synthesized peptide derived from the N-terminal region of human PERK

• Target:

  DKFZp781H1925; E2AK3; EC 2.7.11.1; Eif2ak3; Eukaryotic translation initiation factor 2 alpha kinase 3; Eukaryotic translation initiation factor 2-alpha kinase 3; Heme regulated EIF2 alpha kinase; HRI; HsPEK; Pancreatic eIF2 alpha kinase; Pancreatic eIF2-alpha kinase; PEK; PRKR like endoplasmic reticulum kinase; PRKR-like endoplasmic reticulum kinase; WRS

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC-p; IF

• Field of Research:

  Cancer; Epigenetics and Nuclear Signaling; Metabolism

• Purification:

  Affinity purification

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000

• Buffer:

  PBS with 0.02% sodium azide,0.5% protective protein and 50% glycerol pH 7.4.

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  125kDa

• Observed Molecular Weight:

  125kDa

• Citation 01:

  https://www.mdpi.com/1975256

• Citation 02:

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201986

• Isotype:

  IgG