GSK3 beta Polyclonal Antibody

CAT: 0763-E-AB-31629-01Size: 20 µLDry Ice: NoHazardous: No

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CAT#:0763-E-AB-31629-01Size:20 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.

Abbreviation

GSK3β

UniProt

P49841

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human GSK3β around the non-phosphorylation site of Ser9.

Target

Glycogen Synthase Kinase 3 Beta; Glycogen synthase kinase-3 beta; GSK 3 beta; GSK-3 beta; GSK3B; GSK3B; GSK3beta isoform; Serine/threonine-protein kinase GSK3B

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC-p; IF

Field of Research

Cancer; Cardiovascular; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Purification

Affinity purification

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:100-1:300

Buffer

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

47kDa

Observed Molecular Weight

47kDa

Citation 01

https://www.karger.com/Article/Abstract/452571

Isotype

IgG

UniProtKB · P49841

Glycogen synthase kinase-3 beta

GSK3B_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P49841
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: GSK3B
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: GSK-3 beta
EC number: 2.7.11.26
Processing: —
Secondary accessions: D3DN89, Q9BWH3, Q9UL47

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

ADP-ribosylationLipoproteinPalmitatePhosphoprotein

Coding sequence diversity

Alternative splicing

Disease

Alzheimer diseaseDiabetes mellitus

Ligand

ATP-bindingNucleotide-binding

Biological process

Biological rhythmsCarbohydrate metabolismDifferentiationGlycogen metabolismNeurogenesisWnt signaling pathway

Cellular component

Cell membraneCytoplasmMembraneNucleus

Molecular function

Developmental proteinKinaseSerine/threonine-protein kinaseSignal transduction inhibitorTransferase

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JOT-AP15799-01	GSK3 beta Polyclonal Antibody
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