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FAK Polyclonal Antibody

CAT: 0763-E-AB-31399-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-31399-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
Abbreviation
FAK
UniProt
Q05397
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human FAK around the non-phosphorylation site of Tyr397.
Target
FADK 1; FADK; FAK related non kinase polypeptide; FAK1; FAK1; Focal adhesion kinase 1; Focal adhesion Kinase; Focal adhesion kinase isoform FAK Del33; Focal adhesion kinase related nonkinase; FRNK; p125FAK; pp125FAK; PPP1R71; Protein phosphatase 1 regulatory subunit 71; Protein tyrosine kinase 2; Protein-tyrosine kinase 2; Ptk2; PTK2 protein tyrosine kinase 2
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC-p; IF
Field of Research
Cancer; Cardiovascular; Signal Transduction
Purification
Affinity purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000
Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
119kDa
Observed Molecular Weight
119kDa
Isotype
IgG

UniProtKB · Q05397

Focal adhesion kinase 1

FAK1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q05397
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTK2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
FADK 1
EC number
2.7.10.2
Processing
—
Secondary accessions
B4E2N6, F5H4S4, J3QT16, Q14291, Q8IYN9, Q9UD85
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative promoter usageAlternative splicing

Biological process

Angiogenesis

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell junctionCell membraneCell projectionCytoplasmCytoskeletonMembraneNucleus

Molecular function

Developmental proteinKinaseTransferaseTyrosine-protein kinase

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