PTEN Polyclonal Antibody

• Background :

  PTEN (also designated MMAC1), products of tumor suppressor genes, are found deleted in most human gliomas. The PTEN genes are also mutated in many other tumors, such as brain, breast, kidney and prostate cancers. PTEN is a protein tyrosine phosphatase that may terminate the signaling transduction pathways mediated by PI 3-kinase/Akt. PTEN has an apparent molecular weight of 55 kDa and it is located in the cytosol.

• Abbreviation :

  PTEN

• UniProt :

  P60484

• Host :

  Rabbit

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthetic peptide of human PTEN

• Target :

  10q23del; BZS; DEC; GLM2; MGC11227; MHAM; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; Phosphatase and tensin like protein; Phosphatidylinositol 3;4;5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Pten; PTEN; PTEN1; TEP1

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB; IHC

• Field of Research :

  Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Metabolism; Signal Transduction

• Purification :

  Antigen affinity purification

• Concentration :

  0.9 mg/mL

• Dilution :

  WB 1:500-1:2000; IHC 1:20-1:100

• Buffer :

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  47 kDa

• Observed Molecular Weight :

  Refer to figures

• Citation 01 :

  https://www.sciencedirect.com/science/article/pii/S0168822722008804

• Isotype :

  IgG