PHF21A Polyclonal Antibody

• Background:

  Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. PHF21A (PHD finger protein 21A), also known as BRAF35-HDAC complex protein BHC80, is a 680 amino acid nuclear protein that contains one PHD-type zinc finger and one A.T hook DNA-binding domain, suggesting involvement in transcriptional regulation events. PHF21A is a component of the BHC complex, which is responsible for repressing transcription of neuron-specific genes in non-neuronal cells. The BHC complex acts as a chromatin modifier that deacetylates and demethylates specific sites on histones. PHF21A may act as a scaffold within the BHC complex. Predominantly expressed in brain, three isoforms of PHF21A exist as a result of alternative splicing events.

• Abbreviation:

  PHF21A

• UniProt:

  Q96BD5

• Host:

  Rabbit

• Reactivity:

  Human; Mouse

• Immunogen:

  Fusion protein of human PHF21A

• Target:

  BHC80a; BM-006; BRAF35-HDAC complex protein BHC80; BRAF35/HDAC2 complex (80 kDa) ; KIAA1696; PF21A; PHD finger protein 21A; PHF21A

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC

• Field of Research:

  Epigenetics and Nuclear Signaling; Neuroscience

• Purification:

  Antigen affinity purification

• Concentration:

  0.6 mg/mL

• Dilution:

  WB 1:500-1:2000; IHC 1:40-1:200

• Buffer:

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  75 kDa

• Observed Molecular Weight:

  Refer to figures

• Isotype:

  IgG