CAPN6 Polyclonal Antibody

• Background :

  Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.

• Abbreviation :

  CAPN6

• UniProt :

  Q9Y6Q1

• Host :

  Rabbit

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Fusion protein of human CAPN6

• Target :

  CALP M; Calpain-6; Calpain-like protease X-linked; Calpamodulin; CalpM; CAN6; CANP X; CANPX; CAPN 6; Capn6

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB

• Field of Research :

  Cancer; Cell Biology; Signal Transduction

• Purification :

  Antigen affinity purification

• Concentration :

  0.78 mg/mL

• Dilution :

  WB 1:500-1:2000

• Buffer :

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  75 kDa

• Observed Molecular Weight :

  Refer to figures

• Isotype :

  IgG