KCNN2 Polyclonal Antibody

• Background:

  Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. KCNN2 (Potassium Calcium-Activated Channel Subfamily N Member 2) is a Protein Coding gene. Among its related pathways are Serotonergic synapse and Bile secretion. GO annotations related to this gene include protein homodimerization activity and ion channel activity. An important paralog of this gene is KCNN3.

• Abbreviation:

  KCNN2

• UniProt:

  Q9H2S1

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthetic peptide of human KCNN2

• Target:

  Apamin sensitive small conductance Ca2+ activated potassium; Apamin sensitive small conductance Ca2+ activated potassium channel; hSK2; KCa2.2; Kcnn2; Potassium intermediate/small conductance calcium activated; Potassium intermediate/small conductance calcium activated channel subfamily N member 2; SK2; SKCa 2; SKCa2; Small conductance calcium activated potassium channel; Small conductance calcium activated potassium channel protein 2; Small conductance calcium-activated potassium channel protein 2

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  IHC

• Field of Research:

  Neuroscience

• Purification:

  Antigen affinity purification

• Concentration:

  1.86 mg/mL

• Dilution:

  IHC 1:50-1:300

• Buffer:

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Isotype:

  IgG