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SETD1A Polyclonal Antibody

CAT: 0763-E-AB-18095-02Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-18095-02Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily.
Abbreviation
SETD1A
UniProt
O15047
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide of human SETD1A
Target
Histone-lysine N-methyltransferase SETD1A; hSET1A; KMT2F ; Lysine N methyltransferase 2F; Lysine N-methyltransferase 2F; SET domain containing 1A; SET domain containing protein 1A; SET domain-containing protein 1A; SET1 ; Set1 Ash2 histone methyltransferase complex subunit SET1; Set1/Ash2 histone methyltransferase complex subunit SET1; SET1A ; SET1A; SETD1A
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Epigenetics and Nuclear Signaling
Purification
Antigen affinity purification
Concentration
0.72 mg/mL
Dilution
IHC 1:30-1:150
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · O15047

Histone-lysine N-methyltransferase SETD1A

SET1A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15047
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SETD1A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.1.1.364
Processing
—
Secondary accessions
A0A804HLA6, A6NP62, Q6PIF3, Q8TAJ6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorChromatin regulatorMethyltransferaseRNA-bindingTransferase

Cellular component

ChromosomeCytoplasmNucleus

Disease

Disease variantEpilepsyIntellectual disability

Biological process

DNA damageTranscriptionTranscription regulation

PTM

Phosphoprotein

Ligand

S-adenosyl-L-methionine

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