KCNQ1 Polyclonal Antibody

CAT: 0763-E-AB-15154-01Size: 20 µLDry Ice: NoHazardous: No

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CAT#:0763-E-AB-15154-01Size:20 µL

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Background

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.

Abbreviation

KCNQ1

UniProt

P51787

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant protein of human KCNQ1

Target

ATFB1; ATFB3; FLJ26167; IKs producing slow voltage-gated potassium channel subunit alpha; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; Jervell and Lange-Nielsen syndrome 1; JLNS1; KCNA8; KCNA9; KCNQ1; KCNQ1; kidney and cardiac voltage dependend K+ channel; KQT-like 1; Kv1.9; Kv7.1; KVLQT1; long (electrocardiographic) QT syndrome; Ward-Romano syndrome 1; LQT; LQT1; Potassium channel; voltage-gated; shaker-relatd subfamily; member 9; Potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel; KQT-like subfamily; member 1; RWS; slow delayed rectifier channel subunit; SQT2; Voltage-gated potassium channel subunit Kv7.1; WRS

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Cardiovascular; Metabolism; Neuroscience; Signal Transduction

Purification

Affinity purification

Concentration

0.2 mg/mL

Dilution

WB 1:200-1:1000; IHC 1:50-1:200

Buffer

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

75kDa

Isotype

IgG

UniProtKB · P51787

Potassium voltage-gated channel subfamily KQT member 1

KCNQ1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P51787
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: KCNQ1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: O00347, O60607, O94787, Q14D14, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Atrial fibrillationDeafnessDiabetes mellitusDisease variantLong QT syndromeShort QT syndrome

Molecular function

Calmodulin-bindingIon channelPotassium channelVoltage-gated channel

Cellular component

Cell membraneCytoplasmic vesicleEndoplasmic reticulumEndosomeMembrane

Domain

Coiled coilTransmembraneTransmembrane helix

PTM

GlycoproteinPhosphoproteinUbl conjugation

Biological process

Ion transportPotassium transportTransport

Ligand

Potassium

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