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Factor IX Polyclonal Antibody

CAT: 0763-E-AB-14396-02Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-14396-02Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.
Abbreviation
F9
UniProt
P00740
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human F9
Target
Christmas Disease; Christmas factor; Coagulant factor IX; Coagulation factor 9; Coagulation factor IX; Coagulation factor IXa heavy chain; F9; FA9; Factor 9; Factor IX Deficiency; FactorIX; FIX; Haemophilia B; HEMB; MGC129641; MGC129642; P19; Plasma Thromboplastic Component; Plasma thromboplastin component; PTC
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cardiovascular; Immunology
Purification
Affinity purification
Concentration
0.2 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
52kDa
Isotype
IgG

UniProtKB · P00740

Coagulation factor IX

FA9_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P00740
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
F9
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.22
Processing
Precursor
Secondary accessions
A8K9N4, F2RM36, Q5FBE1, Q5JYJ8
Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Blood coagulationHemostasis

Ligand

CalciumMagnesiumMetal-binding

PTM

Cleavage on pair of basic residuesDisulfide bondGamma-carboxyglutamic acidGlycoproteinHydroxylationPhosphoproteinSulfationZymogen

Disease

Disease variantHemophiliaThrombophilia

Domain

EGF-like domainRepeatSignal

Molecular function

HydrolaseProteaseSerine protease

Cellular component

Secreted

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