MCM6 Polyclonal Antibody

• Background :

  The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.

• Abbreviation :

  MCM6

• UniProt :

  Q14566

• Host :

  Rabbit

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Recombinant protein of human MCM6

• Target :

  DNA replication licensing factor MCM6; MCG40308; Mcm6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog; S. pombe) ; MCM6 minichromosome maintenance deficient 6; MCM6; Minichromosome maintenance complex component 6; Minichromosome maintenance deficient (mis5 S. pombe) 6; Minichromosome maintenance deficient 6 homolog; Minichromosome maintenance protein 6; Mis5; MIS5 homolog; p105MCM

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB; IHC

• Field of Research :

  Cancer; Epigenetics and Nuclear Signaling

• Purification :

  Affinity purification

• Concentration :

  0.8 mg/mL

• Dilution :

  WB 1:500-1:2000; IHC 1:100-1:300

• Buffer :

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  93kDa

• Isotype :

  IgG