MCM3 Polyclonal Antibody

CAT: 0763-E-AB-40230-01Size: 25 µLDry Ice: NoHazardous: No
CAT#:0763-E-AB-40230-01Size:25 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with mCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.
Abbreviation
MCM3
UniProt
P25205
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human DNA replication licensing factor MCM3 protein
Target
Cervical cancer proto oncogene 5; DNA polymerase alpha holoenzyme associated P1; HCC 5; HCC5; hRlf beta subunit; Human cervical cancer proto oncogene 5; MCM 3; MGC1157; Minichromosome maintenance complex component 3; P1 h; P1 MCM3; P1.h; p102; Replication licensing factor beta subunit; RLF beta subunit; RLFB
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Epigenetics and Nuclear Signaling
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:50-1:200
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
91,96 kDa
Observed Molecular Weight
100 kDa
Isotype
IgG
Product Datasheet
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