MCM3 Polyclonal Antibody

• Background :

  The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with mCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.

• Abbreviation :

  MCM3

• UniProt :

  P25205

• Host :

  Rabbit

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Recombinant Human DNA replication licensing factor MCM3 protein

• Target :

  Cervical cancer proto oncogene 5; DNA polymerase alpha holoenzyme associated P1; HCC 5; HCC5; hRlf beta subunit; Human cervical cancer proto oncogene 5; MCM 3; MGC1157; Minichromosome maintenance complex component 3; P1 h; P1 MCM3; P1.h; p102; Replication licensing factor beta subunit; RLF beta subunit; RLFB

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB; IHC

• Field of Research :

  Cancer; Epigenetics and Nuclear Signaling

• Purification :

  Antigen Affinity Purification

• Concentration :

  1 mg/mL

• Dilution :

  WB 1:500-1:1000; IHC 1:50-1:200

• Buffer :

  PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  91,96 kDa

• Observed Molecular Weight :

  100 kDa

• Isotype :

  IgG