NFκB-p105 Polyclonal Antibody

CAT: 0763-E-AB-13851-01Size: 20 µLDry Ice: NoHazardous: No

1 / 1

CAT#:0763-E-AB-13851-01Size:20 µL

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Background

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.

Abbreviation

NFKB1p105

UniProt

P19838

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant protein of human NFKB1p105

Target

DKFZp686C01211; DNA binding factor KBF1; DNA binding factor KBF1 EBP1; DNA-binding factor KBF1; EBP 1; EBP-1; EBP1; KBF1; MGC54151; nf b; NF kappa B; NF kappaB; NF kappabeta; NF kB1; NFkappaB; NFKB 1; NFKB p105; NFKB p50; Nfkb1; NFKB1; Nuclear factor kappa B DNA binding subunit; Nuclear factor kappa-B; subunit 1; Nuclear factor NF kappa B p105 subunit; Nuclear factor NF kappa B p50 subunit; Nuclear factor NF-kappa-B p50 subunit; Nuclear factor of kappa light chain gene enhancer in B cells 1; Nuclear factor of kappa light polypeptide gene enhancer in B cells 1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; p105; p50; p84/NF-kappa-B1 p98; Transcription factor NFKB1

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Immunology; Signal Transduction

Purification

Affinity purification

Concentration

0.3 mg/mL

Dilution

IHC 1:25-1:100

Buffer

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG

UniProtKB · P19838

Nuclear factor NF-kappa-B p105 subunit

NFKB1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P19838
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: NFKB1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A8K5Y5, B3KVE8, Q68D84, Q86V43, Q8N4X7, Q9NZC0

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationHydroxylationIsopeptide bondLipoproteinPhosphoproteinS-nitrosylationUbl conjugation

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Domain

ANK repeatRepeat

Biological process

ApoptosisTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

Related Products

Catalog	Name
E-AB-32226-01	NFκB-p105/p50 Polyclonal Antibody
E-EL-M0836	ELISA kit for Mouse NF-?B p105 (Nuclear factor NF-kappa-B p105 subunit)
E-EL-R0673-01	Rat NFKB-p105 (Nuclear factor NF-kappa-B p105 subunit) ELISA Kit
E-CL-R0110-01	Rat NFKB-p105 (Nuclear factor NF-kappa-B p105 subunit) CLIA Kit
E-EL-H1386-01	Human NFKB-p105 (Nuclear factor NF-kappa-B p105 subunit) ELISA Kit
AN301362L	Recombinant NF-κB1 p105/p50 Monoclonal Antibody
E-AB-32233-01	NFκB-p65 Polyclonal Antibody
E-AB-14244-01	NFκB-p65 Polyclonal Antibody
E-AB-22066-01	NFκB-p65 Monoclonal Antibody
E-AB-22016-01	NFκB-p65 Monoclonal Antibody

Alternative Products

Catalog	Name
ABP55375-01	NF?B-p105 Polyclonal Antibody
RA27782-01	NFκB-p105 Polyclonal Antibody