IPO7 Polyclonal Antibody

CAT: 0763-E-AB-13336-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:0763-E-AB-13336-01Size:20 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.
Abbreviation
IPO7
UniProt
O95373
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Synthetic peptide of human IPO7
Target
FLJ14581; Imp 7; Imp7; Importin-7; Importin7; IPO 7; IPO7; IPO7; MGC138673; Ran binding protein 7; Ran-binding protein 7; RANBP 7; RanBP7
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Epigenetics and Nuclear Signaling; Signal Transduction
Purification
Affinity purification
Concentration
0.5 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:100-1:300
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
120kDa
Isotype
IgG

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